Studies on the Pathogenesis of Rheumatoid Joint Inflammation

Article1 February 1965Studies on the Pathogenesis of Rheumatoid Joint InflammationI. The "R.A. Cell" and a Working HypothesisJOSEPH LEE HOLLANDER, M.D., F.A.C.P., DANIEL J. MCCARTY JR., M.D., F.A.C.P., GONZALO ASTORGA, M.D., EDUARDO CASTRO-MURILLO, M.D.JOSEPH LEE HOLLANDER, M.D., F.A.C.P., DANIEL J. MCCARTY JR., M.D., F.A.C.P., GONZALO ASTORGA, M.D., EDUARDO CASTRO-MURILLO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-271 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe etiology and pathogenesis of rheumatoid arthritis are not known. Many studies have described the clinical and pathological characteristics of the disease process. Numerous additional studies have produced evidence that disorders of immunity are involved, that is, that rheumatoid arthritis and associated diseases may be "immunodyscrasias." Little evidence has been forthcoming to bridge the gap between the clinical features of rheumatoid arthritis and the disordered immunological mechanisms involved.The purpose of this and the next two reports is to describe preliminary findings that may help to clarify the pathogenetic mechanism of rheumatoid arthritis, although the etiology remains unknown. The original...References1. HOLLANDERRAWSONRESTIFOLUSSIER JLAJRAAJ: Studies on the pathogenesis of rheumatoid joint inflammation (abstract). Arthritis Rheum. 7: 314, 1964. Google Scholar2. MCCARTYHOLLANDER DJJL: Identification of urate crystals in gouty synovial fluid. Ann. Intern. Med. 54: 452, 1961. LinkGoogle Scholar3. MCCARTY DJ: Phagocytosis of urate crystals in gouty synovial fluid. Amer. J. Med. Sci. 243: 288, 1962. CrossrefGoogle Scholar4. JACKSON JF: The cytology of the degenerating leukocyte. J. Lab. Clin. Med. 43: 227, 1954. MedlineGoogle Scholar5. IZAKDEVRIES GA: Studies on lipophagocytosis. I. 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Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Arthritis Section, Department of Medicine, Hospital of the University of Pennsylvania, and the Section of Rheumatology, Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia, Pa.Parts of this paper were read in condensed versions before the Eighth Japan Rheumatism Congress in Okayama, Japan, May 20, 1964, and before the Annual Meeting of the American Rheumatism Association in San Francisco, Calif., June 18, 1964 (1). Versions of this paper were also presented before the Australian Rheumatism Congress in Sydney, Australia, September 11, 1963, the Third Pan-American Congress of Rheumatology in Santiago, Chile, October 16, 1963, and the Regional Meeting of the American College of Physicians in Philadelphia, Pa., November 8, 1963.Requests for reprints should be addressed to Joseph L. 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BLUHM, M.D.The adverse effect of intravenous iron-dextran in rheumatoid arthritisTHE DIAGNOSTIC IMPORTANCE OF SYNOVIAL FLUID ANALYSISSerum levels of IgG, IgM, and IgA in rheumatoid arthritis.Early Synovectomy in the Treatment of Rheumatoid ArthritisDemonstration of rheumatoid factor in tissue by mixed agglutination with tissue sectionsViews on the Pathogenesis of Rheumatoid ArthritisMechanisms of Inflammation in Rheumatoid ArthritisRole of Lysosomes in the Pathogenesis of Rheumatoid ArthritisCytotoxic Therapy in Rheumatoid ArthritisA New Type of Inclusion Bodies in LymphocytesRelation of intracytoplasmic inclusions in joint fluid leukocytes to anti-γG globulinsLong-term cyclophosphamide therapy in rheumatoid arthritisSome biological and biochemical consequences of inflammation in connective tissueImmunologic Tissue Injury Mediated by Neutrophilic LeukocytesHaemolytic complement level and ragocyte (R A cell) concentration in synovial fluid.Juvenile Rheumatoid ArthritisRheumatoid PericarditisInduction of proliferative synovitis in rabbits by intra-articular injection of immune complexesRecent Advances in the Rheumatic DiseasesEPHRAIM P. ENGLEMAN, M.D., F.A.C.P., MARTIN A. SHEARN, M.D., F.A.C.P.Arthritis—An Example of Inflammation Based on ParticlesAutosensitivity DiseasesThe Clinical Significance of Deoxyribonucleic Acid Particles in Synovial FluidTHOMAS J. PEKIN JR., M.D., THEODORE I. MALININ, M.D., NATHAN J. ZVAIFLER, M.D.Lysosomes and joint diseaseRheumatoid Arthritis and Its Systemic ManifestationsCARL M. PEARSON, M.D., F.A.C.P., EUGENE BARNETT, M.D., RICHARD KROENING, M.D., LEONARD MARMOR, M.D., JOHN F. MURRAY, M.D., JAMES B. PETER, M.D., PH.D., ALLEN SALICK, M.D.Further studies on the pathogenesis of rheumatoid joint inflammationExamination of Synovial Fluid as a Diagnostic Aid in ArthritisA hypothetical common mechanism in systemic lupus erythematosus and rheumatoid arthritisPleural and Pericardial Effusions in Rheumatoid DiseaseHERBERT W. BERGER, M.D., STANLEY G. SECKLER, M.D.LEUCOCYTES IN RHEUMATOID ARTHRITIS7S AND 19S DERMATOTOXIC GLOBULINSA study of distal interphalangeal joint tenderness in rheumatoid arthritisThe phagosomes in rheumatoid synovial fluid leukocytes: A light, a light, fluorescence, and electron microscope studyNonsteroid Antiinflammatory AgentsPolyarthritis psoriaticaNew thoughts on the pathogenesis of rheumatoid arthritisThe effect of penicillamine on the laboratory parameters in rheumatoid arthritisLysosomesCellular reaction to complexes formed between rheumatoid factor and aggregated human gamma globulin.Studies on the Pathogenesis of Rheumatoid Joint Inflammation III. The Experimental Production of Arthritis by the Intra-articular Injection of Purified 7S Gamma GlobulinRONALD A. RESTIFO, M.D., ANDRE J. LUSSIER, M.D., ARNOLD J. RAWSON, M.D., JOHN H. ROCKEY, M.D., JOSEPH LEE HOLLANDER, M.D., F.A.C.P. 1 February 1965Volume 62, Issue 2Page: 271-280KeywordsArthritisEtiologyHospital medicineInflammationPathogenesisPathogensPhagocytosisRheumatoid arthritisRheumatologySynovial fluid Issue Published: 1 February 1965 PDF DownloadLoading ...