August 16, 2007Clinical Journal of the American Society of Nephrology
Plasma Pentraxin 3 in Patients with Chronic Kidney Disease
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Discussion
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Implication
Cohort study reveals elevated plasma pentraxin 3 predicts mortality in chronic kidney disease, highlighting its potential as a vascular and inflammatory biomarker.
Key Points
- To examine plasma pentraxin 3 concentrations across stages of chronic kidney disease and evaluate their association with glomerular filtration rate, inflammation, protein-energy wasting, and mortality.
- Measured plasma pentraxin 3 levels in 71 patients with stages 3 to 4 chronic kidney disease, 276 patients with stage 5 chronic kidney disease, and 61 control subjects.
- Evaluated associations with glomerular filtration rate, inflammatory markers, cardiovascular disease, and protein-energy wasting, alongside 5-year survival tracking in stage 5 patients.
- Pentraxin 3 concentrations were significantly elevated in patients with chronic kidney disease compared to controls, reaching peak concentrations in stage 5 disease.
- Plasma pentraxin 3 correlated negatively with glomerular filtration rate and positively with inflammatory markers, displaying higher concentrations in patients with protein-energy wasting and cardiovascular disease.
- High pentraxin 3 levels independently predicted increased all-cause and cardiovascular mortality after adjustment for age, sex, C-reactive protein, and cardiovascular disease, performing comparably to interleukin-6.
Cite This Study
Tong et al. (2007) studied this question.