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May link hepatoblastoma to paraneoplastic thrombocytosis via tumor-derived thrombopoietin; hypothesis-generating from single case and unconfirmed.
Two children with hepatoblastoma, marked thrombocytosis, and extremely elevated alpha fetoproteins are reported. It is not clear from review of the literature whether hepatoblastomas or hepatocarcinomas are associated with thrombocytosis. Elevated thrombopoietin levels were found in liver tumor extract from one patient.
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Nickerson et al. (1980) studied this question.
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