Key result
Patients homozygous for the ArgGln haplotype presented consistently higher blood pressure levels following spinal anaesthesia for caesarean delivery compared to those with one or no copies (p=0.001).
Why the study?
Does ArgGln homozygosity of the ADRB2 gene modulate the haemodynamic response following spinal anaesthesia for caesarean delivery in healthy parturients?
Observational (n=143)
Does ArgGln homozygosity of the ADRB2 gene modulate the haemodynamic response following spinal anaesthesia for caesarean delivery in healthy parturients?
p-value: p=0.001
Genetic variations in the ADRB2 gene, specifically ArgGln homozygosity, modulate the haemodynamic response and risk of hypotension following spinal anaesthesia for caesarean delivery.
ArgGln homozygosity was associated with higher post-spinal BP; hypothesis-generating and should not change practice without prospective validation.
We investigated whether genetic variations of the beta-2 adrenergic receptor (ADRB2) modulate the haemodynamic response following spinal anaesthesia for caesarean delivery. We focused on the effects of haplotypes formed by combinations of the Arg16Gly and Gln27Glu polymorphisms. Clinical data from 143 healthy parturients were collected. Only the ArgGln haplotype appeared to influence the risk of hypotension, most probably through a recessive mode of inheritance (p=0.027). Therefore, patients were grouped according to ArgGln homozygosity in two groups: presence of one or no copies of the haplotype (n=120) or two copies of the haplotype (n=23). Both groups presented similar baseline characteristics. Comparatively, patients homozygous for the ArgGln haplotype presented consistently higher blood pressure levels throughout the evaluation period (p=0.001 for systolic arterial pressure variation from baseline). In conclusion, our results demonstrate that haplotype variations of the the ADRB2 modulate the haemodynamic response following spinal anaesthesia for caesarean delivery.
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Daher et al. (2012) conducted an observational in Healthy parturients undergoing spinal anaesthesia for caesarean delivery (n=143). ArgGln haplotype homozygosity (two copies of the haplotype) vs. Presence of one or no copies of the ArgGln haplotype was evaluated on Systolic arterial pressure variation from baseline (p=0.001). Patients homozygous for the ArgGln haplotype presented consistently higher blood pressure levels following spinal anaesthesia for caesarean delivery compared to those with one or no copies (p=0.001).
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