Key result
In females with essential hypertension, GNB3 SNPs and haplotypes were significantly associated with the blood pressure response to atenolol (p < 0.05), with no advantage of haplotypes over SNPs.
Why the study?
Do haplotypes of the adrenergic system predict the blood pressure response to atenolol in patients with essential hypertension?
Observational (n=1,315)
Do haplotypes of the adrenergic system predict the blood pressure response to atenolol in patients with essential hypertension?
p-value: p=<0.05
GNB3 SNPs and haplotypes are associated with blood pressure response to atenolol in women with essential hypertension, though haplotype analysis offers no substantial advantage over SNP analysis.
Requires validation before guiding atenolol use in women; leaves open whether GNB3 haplotypes add value beyond SNPs.
AIMS: To analyze the association of haplotypes of the adrenergic system with essential hypertension and with the blood pressure response to beta-blockers. MATERIALS & METHODS: In 1112 never-treated essential hypertension patients and 203 normotensive controls, tightly linked SNPs of beta-adrenergic receptors (ADRB1 - Ser49Gly and Arg389Gly; ADRB2 - Cys19Arg, Gly16Arg and Gln27Glu) and the G-protein beta3-subunit (GNB3 - A3882C, G5249A and C825T) were genotyped. Association of haplotypes with essential hypertension and with the blood pressure response to atenolol 50 mg twice daily in a subgroup of essential hypertension patients (n = 340) was evaluated (Haploview 3.2). RESULTS: No SNPs or haplotypes were associated with essential hypertension. In females only, GNB3 SNPs and haplotypes were associated with the blood pressure response (p < 0.05). CONCLUSION: Our study confirmed the sex-specific association of GNB3 with the blood pressure response to atenolol with no substantial advantage of the analysis of haplotypes over SNPs.
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Filigheddu et al. (2010) conducted an observational in Essential hypertension (n=1,315). GNB3 SNPs and haplotypes was evaluated on Essential hypertension and blood pressure response to atenolol (p=<0.05). In females with essential hypertension, GNB3 SNPs and haplotypes were significantly associated with the blood pressure response to atenolol (p < 0.05), with no advantage of haplotypes over SNPs.
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