Key result
Endemic PEDV strains from Eastern China belonged to genogroup 2-1 and shared only 88.6%-89.7% nucleotide homology with the CV777 vaccine strain, suggesting the current vaccine may not fully protect pigs.
Why the study?
Porcine epidemic diarrhea virus is a common viral pathogen causing swine diarrhea, prompting genetic evolution analysis of endemic strains in Eastern China.
Cross-Sectional (n=387)
Yes
May reduce CV777 vaccine efficacy against endemic PEDV; leaves open need for updated strain-matched vaccines.
INTRODUCTION: Porcine epidemic diarrhea virus (PEDV) is one of the most common viral pathogens causing swine diarrhea. METHODOLOGY: We performed a genetic evolution analysis of the S1 gene of endemic PEDV strains in Eastern China. The S1 genes of 37 PEDV-positive samples were amplified and sequenced, and compared to the standard CV777 strain, 120 nucleotides were found to have mutations. RESULTS: The nucleotide and deduced amino acid homologies between the sequences and those of the CV777 strain were 90%-91% and 88.2%-90%, respectively, and their homologies to the vaccine strain were 88.6%-89.7% and 86.2%-87.8%, respectively. Genetic evolution and variation analyses indicated that the 37 PEDV strains belonged to genogroup 2-1, while the CV777 strain, vaccine strain, and earlier Chinese strains all belonged to genogroup 1-1. CONCLUSIONS: The newly emerged clinical PEDV strains indicate that the PEDV CV777 vaccine currently used in China may not fully protect pigs from infection with recent epidemic strains, and will require the development of new vaccine strains.
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Jiang et al. (2018) conducted a cross-sectional in Porcine epidemic diarrhea (n=387). PEDV S1 gene sequencing vs. CV777 vaccine strain was evaluated on Nucleotide and amino acid homologies to CV777 strain. Endemic PEDV strains from Eastern China belonged to genogroup 2-1 and shared only 88.6%-89.7% nucleotide homology with the CV777 vaccine strain, suggesting the current vaccine may not fully protect pigs.
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