December 1, 1994Journal of VirologyOpen Access

Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect

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Population

Host cells and nuclear extracts infected with herpes simplex virus type 1 (HSV-1)

Comparison

Infection with wild-type HSV-1 vs Infection with ICP27 viral mutant (27-LacZ)

Design

Preclinical

Authors

Discussion

May guide ICP27-targeted antivirals; leaves open validation in human pathogenesis models.

Population

Host cells and nuclear extracts infected with herpes simplex virus type 1 (HSV-1)

Intervention

Infection with wild-type HSV-1 (expressing immediate-early protein ICP27)

Comparator

Infection with ICP27 viral mutant (27-LacZ)

Outcome

Host cell RNA splicing efficiency and pre-mRNA accumulationsurrogate

HSV-1 infection inhibits host cell RNA splicing through the action of the immediate-early protein ICP27.

Hardy et al. (1994) studied this question.

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