Population
Host cells infected with Herpes simplex virus type 1 or transfected with ICP27 mutants
Comparison
Infection with HSV-1 or transfection with ICP27… vs Uninfected cells or wild-type infected cells
Design
Preclinical
Authors
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May inform HSV-1 host shutoff mechanisms in models; leaves open whether other ICP27 domains or factors complete splicing inhibition.
The redistribution of snRNPs and SC35 by HSV-1 ICP27 correlates with impaired host cell splicing but is not sufficient to fully inhibit it.
Sandri-Goldin et al. (1995) studied this question.
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