Population
In vitro transient expression assays using target plasmids (pTK-CAT and pVP5-CAT)
Comparison
In-frame insertion and deletion mutants in the… vs Wild-type ICP27 or other mutants
Design
Preclinical
Authors
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Carboxy-terminal ICP27 domains are essential for dual regulatory functions; hypothesis-generating for antiviral targeting, should not yet inform practice.
The carboxy-terminal half of the HSV-1 ICP27 protein is essential for its gene activation and repression functions.
Hardwicke et al. (1989) studied this question.
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