Key result
Chronic preoperative SSRI use was identified as an independent risk factor for nonunion following single-level lumbar fusion surgery (OR 1.558, P=0.004).
Why the study?
SSRIs have been linked to decreased bone mineral density and impaired fracture healing, but their relationship with nonunion after spine fusion was unknown.
Does chronic preoperative SSRI use increase the risk of nonunion in patients undergoing single-level lumbar fusion?
Population
7905 single-level lumbar fusion patients
Comparison
Chronic preoperative SSRI use vs no chronic SSRI use
Design
Retrospective national insurance claims database analysis
Follow-up
Between 6 and 24 months
Authors
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May inform preoperative counseling for SSRI users undergoing lumbar fusion; leaves open whether discontinuation reduces nonunion risk.
Cohort (n=7,905)
Yes
Does chronic preoperative SSRI use increase the risk of nonunion in patients undergoing single-level lumbar fusion?
Odds Ratio: 1.558
p-value: p=0.004
Chronic preoperative SSRI use is associated with an increased risk of postoperative nonunion following single-level lumbar fusion.
Pirkle et al. (2020) conducted a cohort in Single-level lumbar fusion (n=7,905). Chronic preoperative selective serotonin reuptake inhibitor (SSRI) prescriptions vs. No chronic SSRI use was evaluated on Nonunion diagnosis between 6 and 24 months following surgery (OR 1.558, p=0.004). Chronic preoperative SSRI use was identified as an independent risk factor for nonunion following single-level lumbar fusion surgery (OR 1.558, P=0.004).
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