What question did this study set out to answer?

To introduce iRefWeb, an interactive web-based platform that consolidates protein-protein interaction records and supporting evidence from ten distinct public databases.

October 12, 2010DatabaseOpen Access

iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence

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Authors

BTBlair TurnerNorthwestern University SRSabry RazickUniversity of Oslo ATAndrei L. TurinskyHospital for Sick Children

Discussion

Member takes

Implication

Database framework demonstrates integration of protein interaction evidence across ten major public repositories, facilitating the curation of reliable organism-specific interactomes.

Key Points

To introduce iRefWeb, an interactive web-based platform that consolidates protein-protein interaction records and supporting evidence from ten distinct public databases.
Aggregated and standardized protein interaction data from 10 public repositories: BIND, BioGRID, CORUM, DIP, IntAct, HPRD, MINT, MPact, MPPI, and OPHID.
Implemented tools to query aggregated interactions, view statistical summaries across databases, trace primary citations, and crop interactomes for specific organisms.
Provides multi-criteria quality assessment metrics, allowing researchers to evaluate interaction reliability based on experimental detection methods, study throughput, and citation counts.
Identifies and compares discrepancies in interaction data extracted from the same scientific publications across different source databases.

Cite This Study

Turner et al. (2010) studied this question.

synapsesocial.com/papers/6a884653b0d802598bf4e636 https://doi.org/10.1093/database/baq023

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October 12, 2010DatabaseOpen Access

iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence

View Full Paper

Ask AI

Bookmark

Authors

BTBlair TurnerNorthwestern University SRSabry RazickUniversity of Oslo ATAndrei L. TurinskyHospital for Sick Children

Discussion

Member takes

Implication

Database framework demonstrates integration of protein interaction evidence across ten major public repositories, facilitating the curation of reliable organism-specific interactomes.

Key Points

To introduce iRefWeb, an interactive web-based platform that consolidates protein-protein interaction records and supporting evidence from ten distinct public databases.
Aggregated and standardized protein interaction data from 10 public repositories: BIND, BioGRID, CORUM, DIP, IntAct, HPRD, MINT, MPact, MPPI, and OPHID.
Implemented tools to query aggregated interactions, view statistical summaries across databases, trace primary citations, and crop interactomes for specific organisms.
Provides multi-criteria quality assessment metrics, allowing researchers to evaluate interaction reliability based on experimental detection methods, study throughput, and citation counts.
Identifies and compares discrepancies in interaction data extracted from the same scientific publications across different source databases.

Cite This Study

Turner et al. (2010) studied this question.

synapsesocial.com/papers/6a884653b0d802598bf4e636 https://doi.org/10.1093/database/baq023

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