What question did this study set out to answer?

To integrate diagnostic predictive models representing protein domains, families, and functional sites from multiple partner databases into a centralized, unified annotation resource.

October 21, 2008Nucleic Acids ResearchOpen Access

InterPro: the integrative protein signature database

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Authors

SHSarah HunterMedical University of South Carolina RARolf ApweilerEuropean Bioinformatics Institute TATeresa K. AttwoodUniversity of Manchester

Discussion

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Implication

Database update demonstrates integration of predictive signatures across 79.8% of UniProtKB proteins, highlighting improved coverage for functional proteome characterization.

Key Points

To integrate diagnostic predictive models representing protein domains, families, and functional sites from multiple partner databases into a centralized, unified annotation resource.
Manually curated and consolidated diagnostic signatures from ten source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY, and TIGRFAMs.
Expanded public data delivery by adding structural annotations, matchless UniProtKB entries to XML files, and direct links to external tools including ADAN, SPICE, and Dasty.
InterPro release v18.0 incorporates 16,549 entries, integrating approximately half of the ~58,000 available source signatures.
The integrated resource successfully matches and annotates 79.8% of sequence records in UniProtKB release v14.1.

Cite This Study

Hunter et al. (2008) studied this question.

synapsesocial.com/papers/69d9a71f387cf70698684ff1 https://doi.org/10.1093/nar/gkn785

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October 21, 2008Nucleic Acids ResearchOpen Access

InterPro: the integrative protein signature database

View Full Paper

Ask AI

Bookmark

Authors

SHSarah HunterMedical University of South Carolina RARolf ApweilerEuropean Bioinformatics Institute TATeresa K. AttwoodUniversity of Manchester

Discussion

Member takes

Implication

Database update demonstrates integration of predictive signatures across 79.8% of UniProtKB proteins, highlighting improved coverage for functional proteome characterization.

Key Points

To integrate diagnostic predictive models representing protein domains, families, and functional sites from multiple partner databases into a centralized, unified annotation resource.
Manually curated and consolidated diagnostic signatures from ten source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY, and TIGRFAMs.
Expanded public data delivery by adding structural annotations, matchless UniProtKB entries to XML files, and direct links to external tools including ADAN, SPICE, and Dasty.
InterPro release v18.0 incorporates 16,549 entries, integrating approximately half of the ~58,000 available source signatures.
The integrated resource successfully matches and annotates 79.8% of sequence records in UniProtKB release v14.1.

Cite This Study

Hunter et al. (2008) studied this question.

synapsesocial.com/papers/69d9a71f387cf70698684ff1 https://doi.org/10.1093/nar/gkn785

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