Key result
High-dose methadone can cause significant QTc prolongation and increase the risk of torsade de pointes, particularly when combined with cytochrome P-450 3A4 inhibitors.
Case Report (n=1)
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Schmittner et al. (2006) conducted a case report in QTc prolongation (n=1). High-dose methadone was evaluated. High-dose methadone can cause significant QTc prolongation and increase the risk of torsade de pointes, particularly when combined with cytochrome P-450 3A4 inhibitors.
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