Key result
High dosages of oral methadone (>600mg/day) were associated with the development of torsades de pointes in three patients, potentially exacerbated by CYP3A4 drug interactions.
Why the study?
Does high dose methadone (>600mg/day) cause torsades de pointes?
Population
3 patients receiving high dosages of oral methadone (>600mg/day), two of whom had previous cardiac impairment.
Design
Case_series
Authors
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High-dose methadone warrants QT vigilance with CYP3A4 inhibitors; case reports leave causal confirmation open.
Case Report (n=3)
Does high dose methadone (>600mg/day) cause torsades de pointes?
High-dose methadone (>600mg/day) is associated with the development of torsades de pointes, highlighting the need for vigilance, especially with concurrent CYP3A4 interacting drugs.
Klein et al. (2003) conducted a case report in Torsades de pointes (n=3). High dose oral methadone was evaluated on Torsades de pointes. High dosages of oral methadone (>600mg/day) were associated with the development of torsades de pointes in three patients, potentially exacerbated by CYP3A4 drug interactions.
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