Key result
White-coat hypertension was independently associated with increased arterial stiffness in treated hypertensive patients (β=1.1; 95% CI 0.1-2.1; P=0.037).
Why the study?
Is white-coat hypertension associated with increased arterial stiffness in treated hypertensive patients?
Cross-Sectional (n=121)
Is white-coat hypertension associated with increased arterial stiffness in treated hypertensive patients?
Effect estimate: β=1.1 (95% CI 0.1-2.1)
p-value: p=0.037
White-coat hypertension is independently associated with increased arterial stiffness in treated hypertensive patients, suggesting a potential high-risk phenotype.
May flag higher-risk treated hypertensives; hypothesis-generating and should not change practice without longitudinal confirmation.
Arterial stiffness, assessed through pulse wave velocity ( PWV ), independently predicts cardiovascular outcomes. In untreated persons, white‐coat hypertension ( WCH ) has been related to arterial stiffness, but data in treated patients with WCH are scarce. The authors aimed to determine a possible association between WCH and arterial stiffness in this population. Adult treated hypertensive patients underwent home blood pressure monitoring and PWV assessment. Variables associated with PWV in univariable analyses were entered into a multivariable linear regression model. The study included 121 patients, 33.9% men, median age 67.9 (interquartile range 18.4) years, 5.8% with diabetes, and 3.3% with a history of cardiovascular or cerebrovascular disease. In multivariable analysis, WCH in treated hypertensive patients remained a determinant of PWV : β=1.1 (95% confidence interval, 0.1–2.1 [ P =.037]; adjusted R 2 0.49). In conclusion, WCH is independently associated with arterial stiffness in treated hypertensive patients. Whether this high‐risk association is offset by antihypertensive treatment should be further investigated.
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Barochiner et al. (2016) conducted a cross-sectional in Treated hypertension (n=121). White-coat hypertension vs. Absence of white-coat hypertension was evaluated on Arterial stiffness assessed through pulse wave velocity (PWV) (β=1.1, 95% CI 0.1-2.1, p=0.037). White-coat hypertension was independently associated with increased arterial stiffness in treated hypertensive patients (β=1.1; 95% CI 0.1-2.1; P=0.037).
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