Key result
Unbiased insertional mutagenesis of the measles virus genome revealed that insertions in the glycoproteins were severely under-represented, suggesting these proteins occupy little evolutionary space.
The inelasticity of measles virus glycoproteins prevents sequence variation required to escape antibody neutralization, explaining the virus's long-lived immunity and monotypic nature.
No takes yet. Share an insight, caveat, or question.
May underpin lifelong measles immunity; leaves open glycoprotein constraints in other viruses.
Fulton et al. (2015) studied Measles virus. Unbiased insertional mutagenesis was evaluated on Tolerance of insertions in the viral genome. Unbiased insertional mutagenesis of the measles virus genome revealed that insertions in the glycoproteins were severely under-represented, suggesting these proteins occupy little evolutionary space.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: