Key result
Myocardial infarction induced widespread transcriptomic alterations across multiple metabolically active tissues at 24 hours, including 3318 differentially expressed genes in the heart.
Why the study?
Myocardial infarction promotes a range of systemic effects, many of which are unknown.
Integrative transcriptomic analysis reveals that myocardial infarction induces widespread, tissue-specific metabolic and transcriptomic alterations across multiple organs beyond the heart.
Animal data on multi-organ transcriptomic shifts post-MI are hypothesis-generating; leaves open human relevance and clinical translation.
Abstract/Summary Myocardial infarction (MI) promotes a range of systemic effects, many of which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, and adipose) in a mouse model of MI (induced by ligating the left ascending coronary artery) and sham-operated mice. We performed a genome-wide transcriptomic analysis on tissue samples obtained 6- and 24-hours post MI or sham operation. By generating tissue-specific biological networks, we observed: (1) dysregulation in multiple biological processes (including immune system, mitochondrial dysfunction, fatty-acid beta-oxidation, and RNA and protein processing) across multiple tissues post MI; and (2) tissue-specific dysregulation in biological processes in liver and heart post MI. Finally, we validated our findings in two independent MI cohorts. Overall, our integrative analysis highlighted both common and specific biological responses to MI across a range of metabolically active tissues.
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A 2020 study studied Myocardial infarction (n=20). Myocardial infarction vs. Sham operation was evaluated on Differentially expressed genes (DEGs) across multiple tissues. Myocardial infarction induced widespread transcriptomic alterations across multiple metabolically active tissues at 24 hours, including 3318 differentially expressed genes in the heart.
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