Key result
Riluzole activates an outward potassium current in mouse superior cervical ganglion neurons that is primarily carried through TREK-2 channels, demonstrating the functional expression of K2P channels in the mammalian autonomic nervous system.
Population
Mouse superior cervical ganglion (mSCG) neurons
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether TREK-2 channels modulate sympathetic function in vivo.
This study provides the first evidence for the expression of K2P channels (TREK-1, TREK-2, TRAAK) in the mammalian autonomic nervous system, specifically in mouse sympathetic neurons.
Cadaveira-Mosquera et al. (2011) studied this question. Riluzole vs. Baseline/Control conditions was evaluated on Activation of outward potassium current (IRIL). Riluzole activates an outward potassium current in mouse superior cervical ganglion neurons that is primarily carried through TREK-2 channels, demonstrating the functional expression of K2P channels in the mammalian autonomic nervous system.
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