Key result
The A-allele of the rs2259816 polymorphism in the HNF1A gene was associated with significantly decreased C-reactive protein levels but did not significantly affect the risk of coronary artery disease (OR 1.049).
Why the study?
Does the rs2259816 polymorphism in the HNF1A gene reduce circulating CRP levels and the risk of coronary artery disease in patients undergoing coronary angiography?
Cohort (n=3,113)
Yes
Does the rs2259816 polymorphism in the HNF1A gene reduce circulating CRP levels and the risk of coronary artery disease in patients undergoing coronary angiography?
Odds Ratio: 1.049 (95% CI 0.866–1.27)
p-value: p=0.626
The rs2259816 polymorphism in the HNF1A gene is associated with decreased CRP levels but not with coronary artery disease, supporting the view that CRP does not play a causal role in the development of CAD.
No CAD risk modification despite lower CRP; leaves open CRP's causal role in CAD pending larger studies.
BACKGROUND: C-reactive protein is a well established marker of inflammation and has been used to predict future cardiovascular disease. It is still controversial if it plays an active role in the development of cardiovascular disease. Recently, polymorphisms in the gene for HNF1α have been linked to the levels of C-reactive protein and coronary artery disease. METHODS: We investigated the association of the rs2259816 polymorphism in the HNF1A gene with the circulating level of C-reactive protein and the hazard of coronary artery disease in the LURIC Study cohort. RESULTS: Compared to CC homozygotes, the level of C-reactive protein was decreased in carriers of at least one A-allele. Each A-allele decreased CRP by approximately 15%. The odds ratio for coronary artery disease was only very slightly increased in carriers of the A-allele and this association did not reach statistical significance. CONCLUSIONS: In the LURIC Study cohort the A-allele of rs2259816 is associated with decreased CRP but not with coronary artery disease.
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Kleber et al. (2010) conducted a cohort in Coronary artery disease (n=3,113). rs2259816 polymorphism in the HNF1A gene (A-allele) vs. CC homozygotes was evaluated on Coronary artery disease (OR 1.049, 95% CI 0.866-1.270, p=0.626). The A-allele of the rs2259816 polymorphism in the HNF1A gene was associated with significantly decreased C-reactive protein levels but did not significantly affect the risk of coronary artery disease (OR 1.049).
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