Why the study?
Does the +1444C>T polymorphism in the CRP gene, which increases CRP levels, increase the risk of non-fatal MI in European men?
Population
10,860 European men
Comparison
Homozygous for the +1444-T allele in the CRP gene vs Other variants of the +1444C>T polymorphism in…
Design
Meta-analysis
Authors
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No excess non-fatal MI risk with CRP-raising genotype; challenges observational CRP–coronary associations as likely confounded.
Does the +1444C>T polymorphism in the CRP gene, which increases CRP levels, increase the risk of non-fatal MI in European men?
This Mendelian randomization study suggests that the association between CRP and coronary events seen in observational studies may be driven by residual confounding or reverse causation rather than a direct causal effect.
Casas et al. (2006) studied this question.
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