Key result
Elevated serum uric acid (upper vs. lowest quartile) was independently associated with abnormal left ventricular global longitudinal strain (adjusted OR 2.28; P=0.020).
Why the study?
Although serum uric acid correlates with oxidative stress and marks poor prognosis in heart failure, its possible association with subclinical left ventricular dysfunction had not been evaluated.
Is elevated serum uric acid associated with subclinical left ventricular dysfunction (abnormal LVGLS) in a general population without overt cardiac disease?
Population
1175 participants from a general population without overt cardiac disease
Comparison
Serum uric acid concentration evaluated as a continuous variable and by quartiles
Design
Community-based cohort study
Authors
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May flag subclinical LV dysfunction in asymptomatic adults; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=1,175)
Is elevated serum uric acid associated with subclinical left ventricular dysfunction (abnormal LVGLS) in a general population without overt cardiac disease?
Odds Ratio: 2.28
p-value: p=0.020
Elevated serum uric acid is independently associated with subclinical left ventricular dysfunction, suggesting it may serve as an early risk marker in individuals without overt cardiac disease.
Nakanishi et al. (2020) conducted a cohort in general population without overt cardiac disease (n=1,175). Elevated serum uric acid vs. Lowest quartile of serum uric acid was evaluated on abnormal LVGLS (greater than -18.6%) (OR 2.28, p=0.020). Elevated serum uric acid (upper vs. lowest quartile) was independently associated with abnormal left ventricular global longitudinal strain (adjusted OR 2.28; P=0.020).
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