Key result
Maximal mitochondrial respiratory rates were reduced by 16.92% in the left ventricular sub-endocardium compared to the sub-epicardium, associated with a two-fold higher nitric oxide production.
Population
23 male Wistar rats (370–470 g)
Comparison
Sub-endocardium myocardial samples and exposure… vs Sub-epicardium (Epi) myocardial samples
Design
Preclinical
Authors
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Subendocardial mitochondrial impairment linked to NO may heighten ischemia risk; leaves open human relevance and therapeutic targeting.
Effect estimate: -16.92%
Absolute Event Rate: 26.07% vs 31.38%
p-value: p=0.040
This preclinical study demonstrates that the left ventricular transmural gradient in mitochondrial respiration is associated with increased nitric oxide and reactive oxygen species production in the sub-endocardium.
Kindo et al. (2016) studied Normal left ventricle (n=23). Sub-endocardium location vs. Sub-epicardium location was evaluated on Maximal mitochondrial respiratory rate (Vmax) (-16.92%, p=0.040). Maximal mitochondrial respiratory rates were reduced by 16.92% in the left ventricular sub-endocardium compared to the sub-epicardium, associated with a two-fold higher nitric oxide production.
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