Population
Wistar rats (3-month-old and 4-month-old) with streptozotocin-induced diabetes mellitus and healthy controls
Comparison
Streptozotocin-induced diabetes and aging vs Healthy age-matched control rats
Design
Preclinical
Follow-up
1 and 2 months
Authors
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Does not yet alter clinical management of diabetic cardiomyopathy; leaves open whether subepicardial changes precede human disease progression.
Mitochondrial dysfunction in diabetic cardiomyopathy appears to begin in the subepicardium before affecting the subendocardium.
MacDonald et al. (2010) studied this question.
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