Total Synthesis of Marinomycins A–C

Ocean's three: Unearthed from the bottom of the ocean off the coast of La Jolla (California, USA), marinomycins A–C, which differ in geometry about the C8C9 and C8′C9′ double bonds, have been prepared by total synthesis through a strategy that features a Suzuki coupling reaction to forge their remarkable polyunsaturated 44-membered-ring systems (see picture).