March 1, 2001FEBS Letters

Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits

View Full Paper

Ask AI

Bookmark

Population

Human genes, brain and kidney tissue for mRNA localization, and Xenopus oocytes for expression studies

Design

Preclinical

Authors

CDChristian DerstParacelsus Medizinische Privatuniversität CKChristine KarschinUniversity of Würzburg EWErhard WischmeyerUniversity of Würzburg

Discussion

Member takes

Implication

No immediate clinical implications; leaves open Kir5.1 modulation of Kir2.1 in human channelopathies.

Structured PICO

Population

Human genes (KCNJ16 and KCNJ2), brain and kidney tissue for mRNA localization, and Xenopus oocytes for expression studies

Intervention

Expression of Kir5.1 and Kir2.1 channel subunits

Outcome

Genetic localization, mRNA expression patterns, and functional channel activitysurrogate

The Kir5.1 subunit is genetically linked to Kir2.1 and functionally interacts with it to negatively regulate inward rectifying potassium channel activity.

Cite This Study

Derst et al. (2001) studied this question.

synapsesocial.com/papers/6a88568d33299ecf904fdc55 https://doi.org/10.1016/s0014-5793(01)02202-5

View Full Paper

Ask AI

Bookmark

Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider