June 1, 2000The Journal of PhysiologyOpen Access

In vivo formation of a proton‐sensitive K+ channel by heteromeric subunit assembly of Kir5.1 with Kir4.1

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Population

Human embryonic kidney HEK293T cells and rat kidney and brain tissues

Comparison

Co-transfection with rat Kir5.1 and Kir4.1 cDNA vs Homomeric Kir4.1 channel

Design

Preclinical

Authors

MTMasayuki TanemotoTokatsu Hospital NKNobuyoshi KittakaOsaka Rosai Hospital AIAtsushi InanobeThe University of Osaka

Discussion

Member takes

Implication

Suggests Kir5.1/Kir4.1 heteromers as renal pH sensors; leaves open their role in human acid-base homeostasis.

Structured PICO

Population

Human embryonic kidney HEK293T cells and rat kidney and brain tissues

Intervention

Co-transfection with rat Kir5.1 and Kir4.1 cDNA

Comparator

Homomeric Kir4.1 channel

Outcome

Functional K+ channel properties and response to internal/external pH levelssurrogate

Kir5.1 co-assembles with Kir4.1 in vivo in the kidney to form a proton-sensitive K+ channel that may sense intracellular pH and regulate acid-base homeostasis.

Cite This Study

Tanemoto et al. (2000) studied this question.

synapsesocial.com/papers/6a8a5843336687a3262e5214 https://doi.org/10.1111/j.1469-7793.2000.00587.x

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