Key result
Kir5.1 channels, both homomeric and heteromeric, play important roles in cellular biological functions and diseases including cardiovascular disease, cancer, and hearing impairment.
Why the study?
Increasing research into Kir channels has drawn attention to the pathophysiological functions of Kir5.1, prompting an overview of its structure, function, and roles in diseases.
This review highlights the emerging pathophysiological roles of the Kir5.1 potassium channel in various diseases, including cardiovascular disease.
Kir5.1 channels may influence arrhythmogenesis and salt-sensitive hypertension; leaves open targeted validation in cardiovascular cohorts.
Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by KCNJ16) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by KCNJ10) or Kir4.2 (encoded by KCNJ15). In most cases, homomeric Kir5.1 is non-functional, while heteromeric Kir5.1 on the cell membrane contributes to the inward flow of K+ ions, which can be regulated by intracellular pH and a variety of signaling mechanisms. In the form of a heterotetramer, Kir5.1 regulates Kir4.1/4.2 activity and is involved in the maintenance of nephron function. Actually, homomeric Kir5.1 may also play a very important role in diseases, including in the ventilatory response to hypoxia and hypercapnia, hearing impairment, cardiovascular disease and cancer. With an increase in the number of studies into the roles of Kir channels, researchers are paying more attention to the pathophysiological functions of Kir5.1. This minireview provides an overview regarding these Kir5.1 roles.
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Zhang et al. (2020) conducted a review in Diseases related to Kir5.1 (hypoxia, hypercapnia, hearing impairment, cardiovascular disease, cancer). Kir5.1 (KCNJ16) was evaluated. Kir5.1 channels, both homomeric and heteromeric, play important roles in cellular biological functions and diseases including cardiovascular disease, cancer, and hearing impairment.
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