Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 2000Journal of Biological ChemistryOpen Access

pH Dependence of the Inwardly Rectifying Potassium Channel, Kir5.1, and Localization in Renal Tubular Epithelia

View Full Paper
Ask AI
Bookmark
Share

Population

Renal tubular epithelial cells

Design

Preclinical

Authors

STStephen J. TuckerPIPaola ImbriciLSLorena Salvatore

Discussion

Loading...

Member takes

Overview

May indicate Kir5.1 as a renal pH sensor; hypothesis-generating for human acid-base disorders and requires validation.

Structured PICO

P
Population
Renal tubular epithelial cells
I
Intervention
Intracellular acidification
O
Outcome
Kir5.1/Kir4.1 heteromeric channel activity and localizationsurrogate

Kir5.1/Kir4.1 heteromeric channels are likely to exist in vivo and are highly sensitive to intracellular acidification, suggesting a novel functional role for the Kir5.1 subunit in renal epithelia.

Cite This Study

Tucker et al. (2000) studied this question.

synapsesocial.com/papers/6a962012fb86bd36df01c67ahttps://doi.org/10.1074/jbc.c000127200
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunolocalization of an inwardly rectifying K+ channel, KAB‐2 (Kir4.1), in the basolateral membrane of renal distal tubular epithelia1996 · 111 citations
  2. 2Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver1999 · 80 citations
  3. 3Opposite effects of pH on open‐state probability and single channel conductance of Kir4.1 channels1999 · 50 citations
  4. 4INWARD RECTIFIER POTASSIUM CHANNELS1997 · 804 citations
  5. 5pH gating of ROMK (K <sub>ir</sub> 1.1) channels: Control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome1999 · 144 citations