Key result
20-HETE exerts both pro- and anti-hypertensive actions by modulating vascular and kidney function, contributing to the pathogenesis of hypertension-associated renal disease.
Design
Review
Authors
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Dual 20-HETE actions in hypertension support targeted research; leaves open clinical translation pending interventional trials.
This review highlights the complex, dual role of 20-HETE in blood pressure regulation and its potential as a therapeutic target in hypertension and renal disease.
Zhang et al. (2018) conducted a review in Hypertension and renal end organ damage. 20-HETE was evaluated. 20-HETE exerts both pro- and anti-hypertensive actions by modulating vascular and kidney function, contributing to the pathogenesis of hypertension-associated renal disease.
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