Key result
Analysis of 307 SNPs across six rhythmonome genes revealed significant allele-frequency and haplotype structure differences among four distinct human populations.
Population
DNA extracted from Coriell cell lines representing four human populations
Design
Preclinical
Authors
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Ethnic variations in rhythmonome genes may inform arrhythmia susceptibility; leaves open pharmacogenomic applications pending clinical validation.
Observational
There are significant ethnic variations and distinct haplotype structures in key genes responsible for cardiac electrical activity, which may influence arrhythmia susceptibility.
Bush et al. (2009) conducted an observational in Arrhythmias. Genetic variation in six rhythmonome genes (ANK2, SCN5A, KCNE1 and 2, KCNQ1, KCNH2, RYR2) vs. Different human populations was evaluated on Allele frequencies and haplotype structure. Analysis of 307 SNPs across six rhythmonome genes revealed significant allele-frequency and haplotype structure differences among four distinct human populations.
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