Why the study?
Does intravenous azimilide suppress inducible ventricular arrhythmias without hemodynamic depression compared to sotalol in a dog model of myocardial infarction?
Population
Anesthetized, male mongrel dogs 4-6 days after surgical infarction of the left ventricle produced by…
Comparison
Intravenous azimilide dihydrochloride vs Intravenous dl-sotalol (0.3-30 mg/kg)
Design
Preclinical
Authors
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May inform azimilide development in arrhythmia models; leaves open translation to human post-MI therapy.
Does intravenous azimilide suppress inducible ventricular arrhythmias without hemodynamic depression compared to sotalol in a dog model of myocardial infarction?
In a canine model of myocardial infarction, intravenous azimilide effectively suppressed inducible ventricular arrhythmias while maintaining hemodynamic stability, unlike sotalol.
Drexler et al. (1996) studied this question.
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