January 1, 1998Japanese Circulation Journal-english EditionOpen Access

Effect of Preischemic Catecholamine Treatment on Ischemia-Reperfusion Injury of the Myocardium

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Why the study?

Does preischemic catecholamine treatment affect postischemic recovery of the myocardium in an isolated rat heart model?

Population

Isolated working heart model from Wistar rats

Design

Preclinical

Authors

YSYasuyuki ShimadaTokyo Medical University FYFumio YamamotoAkita University HYHiroshi YamamotoNational Institute for Environmental Studies

Discussion

Member takes

Implication

Preischemic adrenergic stimulation may impair recovery in this model; leaves open whether calcium modulators protect human myocardium.

Structured PICO

Does preischemic catecholamine treatment affect postischemic recovery of the myocardium in an isolated rat heart model?

Population

Isolated working heart model from Wistar rats

Intervention

Preischemic treatment with catecholamines (isoproterenol 8.0 and 40.0 nmol/L, phenylephrine 0.06, 0.30, and 1.50 micromol/L, or epinephrine 16 and 80 nmol/L) prior to global ischemia (37 degrees C or 20 degrees C) and reperfusion; separate study included calcium modulators (diltiazem and ryanodine)

Outcome

Postischemic recovery of the myocardiumsurrogate

Preischemic catecholamine treatment exerts a deleterious effect on postischemic myocardial recovery, likely mediated by intracellular calcium movement.

Cite This Study

Shimada et al. (1998) studied this question.

synapsesocial.com/papers/6a885e609fc8a8114e4a75a1 https://doi.org/10.1253/jcj.62.517

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Effect of Preischemic Catecholamine Treatment on Ischemia-Reperfusion Injury of the Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Preischemic Catecholamine Treatment on Ischemia-Reperfusion Injury of the Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider