Differential action of KR‐31378, a novel potassium channel activator, on cardioprotective and hemodynamic effects

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Structured PICO

Population

Rats and dogs (conscious and anesthetized models, including coronary occlusion/reperfusion models)

Intervention

KR-31378 (intravenous, doses up to 100 mg/kg in rats, 2 mg/kg in dogs)

Comparator

BMS-191095, lemakalim, and controls

Outcome

Infarct zone size and hemodynamic parameters (blood pressure)surrogate

KR-31378 is a potent cardioprotective agent that reduces infarct size in animal models of ischemia-reperfusion with minimal hypotensive effects.

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Supports further preclinical optimization of KR-31378; leaves open translation to human infarct reduction.

Lee et al. (2001) studied this question.

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