Why the study?
Does SKP-450 reduce arterial pressure in hypertensive rat models and beagle dogs?
Does SKP-450 reduce arterial pressure in hypertensive rat models and beagle dogs?
SKP-450 is a potent, orally active peripheral vasodilator that activates ATP-sensitive potassium channels, effectively lowering blood pressure in animal models.
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SKP-450 merits further preclinical development; leaves open efficacy, safety, and dosing in human hypertension.
Lee et al. (1998) studied this question.
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