Key result
In pithed spontaneously hypertensive rats, cromakalim and SR 44866 significantly decreased regional vasoconstrictor responses to spinal cord stimulation, preferentially affecting the mesentery (-86% and -91%).
p-value: p=<0.05
In spontaneously hypertensive rats, K+ channel openers cromakalim and SR 44866 exert prejunctional sympathoinhibitory effects that are independent of arterial blood pressure and vary by vascular bed.
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K+ channel openers may exert bed-specific sympathoinhibition in hypertensive rat models; leaves open translation to human therapy.
Richer et al. (1990) studied Hypertension (Spontaneously Hypertensive Rats) (n=128). K+ channel openers (cromakalim and SR 44866) vs. Solvent (distilled water-PEG 200 diluted with saline) was evaluated on Systemic pressor and regional vasoconstrictor responses to spinal cord stimulation (p=<0.05). In pithed spontaneously hypertensive rats, cromakalim and SR 44866 significantly decreased regional vasoconstrictor responses to spinal cord stimulation, preferentially affecting the mesentery (-86% and -91%).
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