Population
Electrically paced right ventricular strips from Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Pharmacological modulation of calcium channels… vs Wistar-Kyoto (WKY) normotensive rats
Design
Preclinical
Authors
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Altered Ca2+ handling in hypertensive rat myocardium is hypothesis-generating; leaves open whether L-type channel or ryanodine receptor modulation affects human outcomes.
Hypertension in spontaneously hypertensive rats is associated with altered cardiac calcium homeostasis characterized by increased calcium entry through L-type channels and increased sarcoplasmic reticulum release.
Manso et al. (1999) studied this question.
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