Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 1983Journal of Neurochemistry

Binding of Agonists and Antagonists to Muscarinic Acetylcholine Receptors on Intact Cultured Heart Cells

View Full Paper
Ask AI
Bookmark
Share

Population

Intact cultured cardiac cells

Comparison

Agonists and antagonists vs Homogenized membrane preparations

Design

Preclinical

Authors

NNNeil M. NathansonUniversity of Washington

Discussion

Loading...

Member takes

Implication

Challenges membrane-preparation models for muscarinic binding; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
Intact cultured cardiac cells
I
Intervention
Agonists (carbachol) and antagonists ([3H]quinuclidinyl benzilate and [3H]N-methylscopolamine)
C
Comparator
Homogenized membrane preparations
O
Outcome
Binding affinities and receptor site classessurrogate

This basic science study demonstrates differences in muscarinic acetylcholine receptor binding characteristics between intact cultured heart cells and homogenized membrane preparations.

Cite This Study

Neil M. Nathanson (1983) studied this question.

synapsesocial.com/papers/6a885fd7e8f756f5e66090fdhttps://doi.org/10.1111/j.1471-4159.1983.tb00862.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Muscarinic Cholinergic Binding in Rat Brain1974 · 1,214 citations
  2. 2The biphasic response of muscarinic cholinergic receptors in cultured heart cells to agonists. Effects on receptor number and affinity in intact cells and homogenates.1982 · 108 citations