Why the study?
Does intramuscular injection of naked DNA plasmids encoding IFN-alpha 9 result in in vivo expression of interferon-alpha in adult C57BL/6 mice?
Population
Adult C57BL/6 mice with muscle injury (regenerating tibialis anterior muscles)
Comparison
Intramuscular injection of naked DNA plasmids… vs Blank expression vectors
Design
Preclinical
Follow-up
up to 28 days post-DNA inoculation
Authors
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Establishes a murine model for IFN-alpha 9 expression; extends subtype-specific research but leaves clinical translation open.
Does intramuscular injection of naked DNA plasmids encoding IFN-alpha 9 result in in vivo expression of interferon-alpha in adult C57BL/6 mice?
Intramuscular injection of naked DNA plasmids encoding IFN-alpha 9 successfully induces in vivo expression of the interferon, providing a model to study individual IFN subtypes.
Lawson et al. (1997) studied this question.
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