Key result
A newly isolated murine interferon alpha gene, MuIFN-alpha 8, produces a biologically active protein but is not expressed in murine fibroblasts upon virus induction.
Population
Murine fibroblastic cosmid library, COS cells, oocytes, and murine fibroblasts
Design
Preclinical
Authors
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MuIFN-alpha 8 identified as new family member; leaves open its functional role in antiviral responses pending further study.
Identifies a new functional murine interferon alpha gene (MuIFN-alpha 8) that produces an active antiviral protein but lacks expected expression in virus-induced fibroblasts.
Navarro et al. (1989) studied this question. MuIFN-alpha 8 gene expression was evaluated on Biological activity and expression of MuIFN-alpha 8 gene. A newly isolated murine interferon alpha gene, MuIFN-alpha 8, produces a biologically active protein but is not expressed in murine fibroblasts upon virus induction.
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