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August 1, 1991Archives of Internal Medicine

Low-Molecular-Weight Heparin (Enoxaparin) vs Dextran 70

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Why the study?

Does enoxaparin reduce deep vein thrombosis in patients undergoing elective total hip replacement compared to dextran 70?

Population

246 patients undergoing elective total hip replacement (219 eligible for analysis)

Comparison

Enoxaparin 40.6 mg subcutaneously once daily vs Standard regimen of dextran 70

Design

RCT, randomized

Follow-up

7 to 11 days (with some follow-up to 15 days post-discharge)

Discussion

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Member takes

Overview

Favors enoxaparin over dextran for DVT prophylaxis after elective hip replacement; extends LMWH evidence in orthopedic surgery.

Structured PICO

Does enoxaparin reduce deep vein thrombosis in patients undergoing elective total hip replacement compared to dextran 70?

P
Population
246 patients undergoing elective total hip replacement (219 eligible for analysis)
I
Intervention
Enoxaparin 40.6 mg subcutaneously once daily
C
Comparator
Standard regimen of dextran 70
O
Outcome
Deep vein thrombosis diagnosed by bilateral ascending phlebography 7 to 11 days after operationhard clinical

Enoxaparin is more effective than dextran 70 for preventing deep vein thrombosis after total hip replacement, without increasing bleeding risk.

Cite This Study

A 1991 study studied this question.

synapsesocial.com/papers/6a88624a2d13770579f4ec8ahttps://doi.org/10.1001/archinte.1991.00400080105020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of deep vein thrombosis in patients with hip fractures: Low molecular weight heparin versus dextran1992 · 20 citations
  2. 2Use of enoxaparin, a low-molecular-weight heparin, and unfractionated heparin for the prevention of deep venous thrombosis after elective hip replacement. A clinical trial comparing efficacy and safety. Enoxaparin Clinical Trial Group.1994 · 221 citations
  3. 3Comparison of two low-molecular-weight heparins for the prevention of postoperative venous thromboembolism after elective hip surgery1998 · 48 citations
  4. 4Prevention of Postoperative Venous Thrombosis: A Randomized Trial Comparing Unfractionated Heparin with Low Molecular Weight Heparin in Patients Undergoing Total Hip Replacement1988 · 256 citations
  5. 5Prevention of Deep-Vein Thrombosis following Total Hip Replacement Surgery with Enoxaparin versus Unfractionated Heparin: A Pharmacoeconomic Evaluation1994 · 47 citations