January 16, 1987Science

A Subset of Yeast snRNA's Contains Functional Binding Sites for the Highly Conserved Sm Antigen

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Population

Xenopus eggs or oocytes injected with labeled yeast snRNA's from Saccharomyces cerevisiae

Design

Preclinical

Authors

NRN RiedelUniversity of California, San Francisco SWSandra L. WolinFrederick National Laboratory for Cancer Research CGChristine GuthrieUniversity of California, San Francisco

Discussion

Member takes

Implication

Does not yet inform clinical autoimmunity; extends evidence for spliceosomal Sm-site conservation across eukaryotes.

Structured PICO

Population

Xenopus eggs or oocytes injected with labeled yeast snRNA's from Saccharomyces cerevisiae

Intervention

Microinjection of labeled yeast snRNA's

Outcome

Immunoprecipitability with human auto-antibodies (anti-Sm)

Yeast contains functional analogues of Sm snRNA's with a conserved Sm binding site, demonstrating evolutionary conservation of this spliceosome component.

Cite This Study

Riedel et al. (1987) studied this question.

synapsesocial.com/papers/6a8863a55ee6e03ae3cf2140 https://doi.org/10.1126/science.2948278

View Full Paper

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A Subset of Yeast snRNA's Contains Functional Binding Sites for the Highly Conserved Sm Antigen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Subset of Yeast snRNA's Contains Functional Binding Sites for the Highly Conserved Sm Antigen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider