Population
Constitutive and muscle-specific cofilin-2-deficient mice generated using a cre-loxP strategy
Comparison
Cofilin-2 knockout (Cfl2 knockout) vs Wild-type (WT) littermates
Design
Preclinical
Follow-up
up to 8 days
Authors
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Cofilin-2 is essential for postnatal muscle maintenance in mice; leaves open its role in human sarcomeric disease and need for validation.
Cofilin-2 is essential for muscle maintenance, as its deficiency in mice leads to progressive sarcomeric disruption and early postnatal death.
Agrawal et al. (2012) studied this question.
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