Why the study?
Does transdermal nitroglycerin alter haemodynamic parameters in healthy volunteers?
Does transdermal nitroglycerin alter haemodynamic parameters in healthy volunteers?
Transdermal nitroglycerin at standard doses produces venodilatation but induces reflex increases in heart rate and inotropy, suggesting larger doses are needed for anti-anginal effects.
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Reflex venodilation from standard transdermal nitroglycerin is offset by increased inotropy in volunteers; leaves open optimal dosing for anti-anginal benefit.
Bennett et al. (1985) studied this question.
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