The Significance of the Lupus Globulin-Nucleoprotein Reaction

Article1 October 1958THE SIGNIFICANCE OF THE LUPUS GLOBULIN-NUCLEOPROTEIN REACTIONGEORGE J. FRIOU, M.D.GEORGE J. FRIOU, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-4-866 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe description of the L.E. phenomenon by Hargraves is recognized as an important milestone in the advance of our knowledge of the rheumatic diseases.1 This observation has aroused a great increase in interest in disseminated lupus erythematosus. In particular, the L.E. phenomenon has attracted the attention of investigators because of the feeling that knowl-edge of its mechanisms would reveal other important clues regarding the disease. Presented here is a review of some recent investigations related to this problem.INTERACTION OF LUPUS GLOBULIN AND NUCLEIParticularly pertinent to our discussion is the work of Haserick,2who demonstrated that the L.E. factor...Bibliography1. HargravesRichmondMorton MHR: Presentation of two bone marrow elements: the "Tart" cell and the "L.E." cell, Proc. Staff Meet., Mayo Clin. 23: 25, 1948. MedlineGoogle Scholar2. HaserickLewisBortz JRLADW: Blood factor in acute disseminated lupus erythematosus. I. Determination of gamma globulin as specific plasma fraction, Am. J. M. Sc. 219: 660, 1950. CrossrefMedlineGoogle Scholar3. MiescherFauconnet PM: L'absorption du facteur "L.E." par des royaux cellu-laires isoles, Experentia 10: 252, 1954. CrossrefMedlineGoogle Scholar4. FriouFinchDetre GSK: Nuclear localization of a factor from disseminated lupus serum, Federation Proc. 16: 413, 1957. Google Scholar5. FriouFinchDetre GSK: Interaction of nuclei and globulin from lupus erythe-matosus serum demonstrated with fluorescent antibody, J. Immunol. 80: 324, 1958. MedlineGoogle Scholar6. CoonsKaplan AM: Localization of antigen in tissue cells. II. Improvements in a method for the detection of antigen by means of fluorescent antibody, J. Exper. Med. 91: 1, 1950. CrossrefMedlineGoogle Scholar7. HolmanKunkel HH: Affinity between the lupus erythematosus serum factor and cell nuclei and nucleoprotein, Science 126: 162, 1957. CrossrefMedlineGoogle Scholar8. HolborowWeirJohnson EDG: A serum factor in lupus erythematosus with affinity for tissue nuclei, Brit. M. J. 2: 732, 1957. CrossrefMedlineGoogle Scholar9. GodmanDeitch GCAD: A cytochemical study of the L.E. bodies of systemic lupus erythematosus. I. Nucleic acids. II. Proteins, J. Exper. Med. 106: 575, 593, 1957. CrossrefMedlineGoogle Scholar10. LeeMichaelVural SSL: The L.E. (lupus erythematosus) cell, Am. J. Med. 10: 446, 1951. CrossrefMedlineGoogle Scholar11. Friou G: Clinical application of lupus serum-nucleoprotein reaction using the fluorescent antibody technique, J. Clin. Investigation 36: 890, 1957. Google Scholar12. Friou G: Identification of the nuclear component of the interaction of lupus erythema-tosus globulin and nuclei, J. Immunol. 80: 476, 1958. MedlineGoogle Scholar13. Friou G: Clinical application of a test for lupus globulin-nucleohistone interaction using fluorescent antibody, Yale J. Biol. and Med. 31: (Sept.) 1958. MedlineGoogle Scholar14. Dubois E: Systemic lupus erythematosus: recent advances in its diagnosis and treat-ment, Ann. Int. Med. 45: 163, 1956. LinkGoogle Scholar15. FinchDetre SK: Leukotoxicity of pathologic sera and certain drugs, Clin. Res. 6: 196, 1958. Google Scholar16. SeiwaldRiggsBurckhalterDownsMetcalf RJJCT: Isothiocyanate compounds as fluorescent labeling agents for immune serums, in Abstracts of 58th Annual Meeting, Society of American Bacteriologists, Bacteriological Proceedings, to be published. Google Scholar17. Friou G: Improved method for measuring lupus globulin nucleoprotein interaction, Proc. Scc. Exper. Biol. and Med. 97: 738, 1958. CrossrefMedlineGoogle Scholar18. RobbinsHolmanDeicherKunkel WHHH: Complement fixation with cell nuclei and DNA in lupus erythematosus, Proc. Soc Exper. Biol, and Med. 96: 575, 1957. CrossrefMedlineGoogle Scholar19. Gajdusek C: An "autoimmune" reaction against human tissue antigens in certain acute and chronic diseases, Arch. Int. Med. 101: 9, 1958. CrossrefGoogle Scholar20. Dameshek W: Systemic lupus erythematosus: a complex auto-immune disorder, Ann. Int. Med. 48: 707, 1958. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE J. FRIOU, M.D.Affiliations: West Haven, Connecticut*Presented at the Thirty-ninth Annual Session of the American College of Physicians, Atlantic City, New Jersey, May 2, 1958.From the Medical Service of the Veterans Administration Hospital, West Haven, Con-necticut, and the Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.†Support for this investigation was provided by the Veterans Administration, and re-search grants from the Connecticut Heart Association and U. S. Public Health Service (USPHS E-1952).Requests for reprints should be addressed to George J. Friou, M.D., Chief, Infectious Diseases Section, Medical Service, Veterans Administration Hospital, West Haven 16, Connecticut. 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WILSON JR., M.D.Incidence of the Anti-Nuclear Factor in Human SeraAntinuclear antibodies in systemic lupus erythematosusAbnormal Serum Proteins as Aids in Diagnosis of Rheumatoid Arthritis and Systemic Lupus Erythematosus 1 October 1958Volume 49, Issue 4Page: 866-875KeywordsAttentionEmotionsHeartHospital medicineLupus erythematosusMedical servicesPathogenesis ePublished: 1 December 2008 Issue Published: 1 October 1958 PDF downloadLoading ...