The enantioselectivity of modified cyclodextrins: Studies on interaction mechanisms

The separation of enantiomers of rather simple molecules, such as alkanes and alkanoic acid esters substituted at the 2‐position, has been investigated on alkylated β‐cyclodextrin stationary phases. By observing the effect of varying the substrate and the cyclodextrin alkylating agent it has been possible to propose a mechanism for the separation. The most important factors seem to be hydrophobic interactions and the ability of the cyclodextrin to change its conformation to accept the guest molecule.