Novel chloride conductance in the membrane of bovine chromaffin cells activated by intracellular GTP gamma S.
Population
Perfused bovine chromaffin cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; leaves open the physiological role of this G-protein-linked Cl− conductance in secretory cells.
Structured PICO
P
Population
Perfused bovine chromaffin cells
I
Intervention
Intracellular introduction of GTP gamma S (5-300 microM)
O
Outcome
Activation of transient current and [Ca2+]i oscillationssurrogate
Intracellular GTP gamma S activates a novel chloride conductance in bovine chromaffin cells, likely via a G protein-mediated second messenger.
Cite This Study
Doroshenko et al. (1991) studied this question.