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Na + transport was measured in the Ehrlich mouse ascites tumor cell by isotopic and chemical methods. Evidence for an initial, rapidly exchanging Na + compartment was found in addition to a slower compartment. Net Na + efflux might constitute less than half the total efflux. Influx of Na + decreased while intracellular Na + was falling, demonstrating a dependence of Na + influx on intracellular Na + content. Taken together, the data provide evidence for a component of Na + transport which is mediated but not active.
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Aull et al. (1963) studied this question.
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