Why the study?
Do patients with normal renin essential hypertension have altered plasma kinin levels and urinary kallikrein excretion compared to normotensive subjects?
Population
51 subjects, similar with regard to age, sex, and race distribution, studied in balance on a diet containing…
Design
Case-control
Authors
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Normal plasma kinin levels in normal-renin hypertension; leaves open whether reduced urinary kallikrein contributes to pathogenesis.
Do patients with normal renin essential hypertension have altered plasma kinin levels and urinary kallikrein excretion compared to normotensive subjects?
Patients with normal renin essential hypertension have normal plasma kinin levels despite subnormal urinary kallikrein excretion, suggesting that altered circulating kinin does not contribute to their hypertension.
Mersey et al. (1979) studied this question.
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