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December 1, 1974Circulation ResearchOpen Access

Urinary Kallikrein Excretion in Normal Man

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Authors

HMHarry S. MargoliusMedical University of South CarolinaDHDavid L. HorwitzLouisiana State UniversityRGRonald G. GellerNational Heart Lung and Blood Institute

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Implication

Physiological study reveals that urinary kallikrein excretion is regulated by sodium intake and mineralocorticoid activity in healthy adults, indicating a renal role in sodium balance.

Key Points

  • To evaluate how changes in dietary sodium intake, mineralocorticoid activity, and acute volume expansion influence urinary kallikrein excretion in healthy human volunteers.
  • Measured daily urinary kallikrein, amylase, aldosterone excretion, and plasma renin activity across varying dietary sodium regimens (ad libitum, 109 mEq/day, 9 mEq/day, and 259 mEq/day).
  • Administered fludrocortisone (0.5 mg/day for 10 days) on a fixed sodium-potassium intake and spironolactone (400 mg/day) during severe sodium restriction (9 mEq/day).
  • Tested acute fluid loading through rapid oral water administration (1 to 2 L in 30 minutes) and rapid intravenous normal saline infusion (2.4 L).
  • Restricting sodium intake to 9 mEq/day progressively increased urinary kallikrein excretion in all subjects to a mean maximal value of 271% of control by day 7, returning to control values at 259 mEq/day.
  • Treatment with fludrocortisone increased urinary kallikrein excretion to a mean maximal value of 203% of control, whereas spironolactone significantly decreased the elevated kallikrein excretion induced by sodium restriction.
  • Acute expansion with oral water or intravenous saline did not significantly alter kallikrein excretion, despite substantial changes in urine volume and sodium output.

Cite This Study

Margolius et al. (1974) studied this question.

synapsesocial.com/papers/6a8877fe4c82be800eeb6471https://doi.org/10.1161/01.res.35.6.812
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Altered Urinary Kallikrein Excretion in Rats with Hypertension1972 · 149 citations