Population
Natriuretic peptide receptors (NPR-A and NPR-B) in biochemical assays
Comparison
Absence of ATP or addition of nonhydrolyzable… vs Standard ATP-dependent activation models
Design
Preclinical
Authors
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Challenges ATP-dependence model in animal natriuretic peptide receptors; hypothesis-generating for human receptor function and therapeutic implications.
This study challenges the prevailing model by demonstrating that ATP is not required for the activation of natriuretic peptide receptors, but instead functions to stabilize the enzyme and maintain phosphorylation.
Antos et al. (2005) studied this question.
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